PolysacDB Lipopolysaccharide 1358

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Chlamydia trachomatis serotype E

[edit] Basic Structure

The LPS is composed of the pentasaccharide bisphosphate αKdo-(2-8)-αKdo-(2-->4)-αKdo-(2-6)-βGlcN-4P-(1-->6) αGlcN-1P (Kdo is 3-deoxy-α-d-manno-oct-2-ulosonic acid)

[edit] Proposed functions

LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin

[edit] Antigenic Nature used to produce antibodies

elementary bodies of Chlamydia trachomatis serotype E

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab EV1-H1

[edit] Antibody type and class

IgG2a

[edit] Assay System

IFT assay, ELISA

[edit] Cross-reactivity

This antibody cross-reacted with Salmonella Minnesota LPS and Chlamydia psittaci

[edit] Proposed epitopes

The epitope cosisted of a trisaccharide of a-3-deoxy-D-manno-2-octulosonic acid (KDO)

[edit] Proposed Utility

This Mab can be used in the epitope characterization of Chlamydial LPS

[edit] Weblink

PubMed Central

[edit] External Links

• BCSDB Structural Detail

• IEDB Epitopic Detail

• Link to PolysacDB database