PolysacDB High molecular weight polysaccharide 1108
From DrugPedia: A Wikipedia for Drug discovery
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[edit] Carbohydrate Name
High molecular weight polysaccharide
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Actinobacillus pleuropneumoniae serotype 4 (field isolate F6)
[edit] Basic Structure
N/A
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
formalin-fixed A. pleuropneumoniae serotype 4 cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab 5H7
[edit] Antibody type and class
IgM
[edit] Assay System
Whole cell ELISA and slide agglutination tests
[edit] Cross-reactivity
This Mab failed to recognize surface epitopes located on other bacterial, such as H. parasuis, P. haemolytica, P. multocida capsular types A and D, Haemophilus taxon minor group, and A. suis, K. pneumoniae and B. bronchiseptica. This Mab exhibited 75.8 and 27.3% reactivities with 29 serotype 4 and 12 serotype7 isolates, respectively, and partial binding to serotype 1 and nontypeable isolates
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This MAb could be useful for the serological diagnostic of animals infected with serotypes 4 and 7 by inhibition ELISA or competition ELISA. Moreover, they could be useful as complementary reagents to polyclonal sera for serotyping of field isolates belonging to A. pleuropneumoniae serotype 4 or 7
