Immunotation of Rv3459c

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| PDB        = 2wdh
| PDB        = 2wdh
| DrugBank          =
| DrugBank          =
-
| chemical_formula  = [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=7711&loc=ec_rcs]
+
| chemical_formula  =
| molecular_weight  = 147848.8 Da
| molecular_weight  = 147848.8 Da
| solubility        =  
| solubility        =  
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}}
}}
=General=
=General=
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S11 PLAYS AN ESSENTIAL ROLE FOR THE SELECTION OF THE CORRECT TRNA IN PROTEIN BIOSYNTHESIS.  
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'''S11 PLAYS AN ESSENTIAL ROLE FOR THE SELECTION OF THE CORRECT TRNA IN PROTEIN BIOSYNTHESIS.  
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IT IS LOCATED ON THE LARGE LOBE OF THE SMALL SUBUNIT
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IT IS LOCATED ON THE LARGE LOBE OF THE SMALL SUBUNIT'''
Rv3459c, (MTCY13E12.12c), len: 139 aa. Probable rpsK, 30S ribosomal protein S11, equivalent to Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S RIBOSOMAL PROTEIN S11 from Mycobacterium leprae (138 aa), FASTA scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa overlap); and P45812|RS11_MYCBO 30S RIBOSOMAL PROTEIN S11 from Mycobacterium bovis (139 aa), FASTA scores: opt: 867, E(): 8.4e-47, (94.25% identity in 139 aa overlap). Also highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 from Streptomyces coelicolor (134 aa), FASTA scores: opt: 729, E(): 2.6e-38, (79.85% identity in 139 aa overlap); O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 aa), FASTA scores: opt: 618, E(): 1.7e-31, (70.3% identity in 128 aa overlap); P04969|RS11_BACSU|RPSK from Bacillus subtilis (131 aa), FASTA scores: opt: 601, E(): 2e-30, (69.0% identity in 129 aa overlap); etc. Contains ribosomal protein S11 signature (PS00054). BELONGS TO THE S11P FAMILY OF RIBOSOMAL PROTEINS.
Rv3459c, (MTCY13E12.12c), len: 139 aa. Probable rpsK, 30S ribosomal protein S11, equivalent to Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S RIBOSOMAL PROTEIN S11 from Mycobacterium leprae (138 aa), FASTA scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa overlap); and P45812|RS11_MYCBO 30S RIBOSOMAL PROTEIN S11 from Mycobacterium bovis (139 aa), FASTA scores: opt: 867, E(): 8.4e-47, (94.25% identity in 139 aa overlap). Also highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 from Streptomyces coelicolor (134 aa), FASTA scores: opt: 729, E(): 2.6e-38, (79.85% identity in 139 aa overlap); O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 aa), FASTA scores: opt: 618, E(): 1.7e-31, (70.3% identity in 128 aa overlap); P04969|RS11_BACSU|RPSK from Bacillus subtilis (131 aa), FASTA scores: opt: 601, E(): 2e-30, (69.0% identity in 129 aa overlap); etc. Contains ribosomal protein S11 signature (PS00054). BELONGS TO THE S11P FAMILY OF RIBOSOMAL PROTEINS.
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MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENA
MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENA
ARKAQDHGVRKVDVFVKGPGSGRETAIRSLQAAGLEVGAISDVTPQPHNGVRPPKRRRV
ARKAQDHGVRKVDVFVKGPGSGRETAIRSLQAAGLEVGAISDVTPQPHNGVRPPKRRRV
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=Human Homologue Blast Result=
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 +
<table border='1'><tr>
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<td>subject ids</td><td>% identity</td><td>% positives</td><td>alignment length</td><td> evalue</td></tr>
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<tr><td> sp|P82912.2</td><td> 44</td><td> 61</td><td> 109</td><td> 3e-15 </td></tr>
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<tr><td> sp|P62263.3</td><td> 34</td><td> 58</td><td> 117</td><td> 2e-13</td></tr>
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<tr><td> sp|Q9UH73.2</td><td> 27</td><td> 38</td><td> 73</td><td> 0.24</td></tr>
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<tr><td> sp|Q12800.2</td><td> 26</td><td> 42</td><td> 61</td><td> 0.47</td></tr>
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<tr><td> sp|Q8WW22.1</td><td> 31</td><td> 37</td><td> 58</td><td> 1.4</td></tr></table>
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=Alergen Protein=
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Link to [http://www.imtech.res.in/raghava/algpred/ Algpred]<br>
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ALLERGEN (By IgE method)
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NON ALLERGEN
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=Bacterial Toxin Prediction=
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Link to [http://www.imtech.res.in/raghava/btxpred/submission.html btxpred]<br>
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No Hit Fountd by btxpred server.
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=Subcellular Location=
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Link to [http://www.imtech.res.in/raghava/tbpred/ TBpred]<br>
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PROTEIN ATTACHED TO MEMBRANE BY LIPID ANCHOR
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=Antigens=
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No Hit Found in [http://www.imtech.res.in/raghava/antigendb/keyquery.html AntigenDB]<br>
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No. Hit Found in [http://www.iedb.org/ IEDB]
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==B cell Epitopes==
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====BCEpred Analysis====
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Link to [http://www.imtech.res.in/raghava/bcepred/bcepred_submission.html Bcepred]  
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<br>
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Result Predicited by [http://crdd.osdd.net/drugpedia/index.php/Image:ABCpred_Prediction_Server3459c.doc]<br>
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====ABCpred Analysis====
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Link to [http://www.imtech.res.in/raghava/abcpred/ABC_submission.html ABCpred]<br>
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Result Predicited by[http://crdd.osdd.net/drugpedia/index.php/Image:BcePred_Prediction_Serverresult_3459c.doc]<br>
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====IEDB Analysis====
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Link to [http://tools.immuneepitope.org/tools/bcell/iedb_input IEDB]<br>
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Result Predicited by [http://crdd.osdd.net/drugpedia/index.php/Image:IEDB_Analysis_Resource3459c.doc]<br>
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=MHC Class-I Binder=
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==nHLAPred Analysis==
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Link to [http://www.imtech.res.in/raghava/nhlapred/comp.html nHLApred]
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<br>
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Result Predicited by [http://crdd.osdd.net/drugpedia/index.php/Image:NHLAPred3459c.doc]<br>
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==IEDB Analysis==
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Link to [http://tools.immuneepitope.org/analyze/html/mhc_processing.html IEDB] <br>
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Result Predicted by [http://crdd.osdd.net/drugpedia/index.php/Image:IEDB_Analysis_Resource3459c_MHC1-1.doc]<br>
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Result Predicted by [http://crdd.osdd.net/drugpedia/index.php/Image:MHC-1-2.doc]<br>
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=MHC Class-II Binder=
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==Propred Analysis==
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Link to [http://www.imtech.res.in/raghava/propred/ Propred]<br>
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Result Predicted by[http://crdd.osdd.net/drugpedia/index.php/Image:MHC_Class-II_prophed3459c.doc]<br>
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==NetMHC-II Analysis==
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Link to [http://www.cbs.dtu.dk/services/NetMHCII/ NetMHC-II]<br>
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Result Predicted by [http://crdd.osdd.net/drugpedia/index.php/Image:NetMHCII3459c.doc]
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=External Links=
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* [http://www.biohealthbase.org/mycobacterium Database] of ''Mycobacterium tuberculosis'' genome sequences and related information.
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[[Category:C2D]]
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[[Category:Mtb Immunotation]]

Current revision

Immunotation of Rv3459c
Name
PROBABLE 30S RIBOSOMAL PROTEIN S11 RPSK
Identifiers
Swiss Prot O06326
Genbank [http://www.ncbi.nlm.nih.gov/nuccore/57116681?report=genbank&log$=seqview&from=3879273&to=3879692 NC_000962[1]]
PDB 2wdh
Chemical data
Formula  ?
Mol. wt. 147848.8 Da
Pharmacokinetic data
Bioavailability  ?
Solubility  ?
Isoelectric-Point 12.22

Contents

[edit] General

S11 PLAYS AN ESSENTIAL ROLE FOR THE SELECTION OF THE CORRECT TRNA IN PROTEIN BIOSYNTHESIS. IT IS LOCATED ON THE LARGE LOBE OF THE SMALL SUBUNIT Rv3459c, (MTCY13E12.12c), len: 139 aa. Probable rpsK, 30S ribosomal protein S11, equivalent to Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S RIBOSOMAL PROTEIN S11 from Mycobacterium leprae (138 aa), FASTA scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa overlap); and P45812|RS11_MYCBO 30S RIBOSOMAL PROTEIN S11 from Mycobacterium bovis (139 aa), FASTA scores: opt: 867, E(): 8.4e-47, (94.25% identity in 139 aa overlap). Also highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 from Streptomyces coelicolor (134 aa), FASTA scores: opt: 729, E(): 2.6e-38, (79.85% identity in 139 aa overlap); O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 aa), FASTA scores: opt: 618, E(): 1.7e-31, (70.3% identity in 128 aa overlap); P04969|RS11_BACSU|RPSK from Bacillus subtilis (131 aa), FASTA scores: opt: 601, E(): 2e-30, (69.0% identity in 129 aa overlap); etc. Contains ribosomal protein S11 signature (PS00054). BELONGS TO THE S11P FAMILY OF RIBOSOMAL PROTEINS.

[edit] Protein Sequence

>Rv3459c, TB.seq 3879272:3879688 MW:14786

MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENA ARKAQDHGVRKVDVFVKGPGSGRETAIRSLQAAGLEVGAISDVTPQPHNGVRPPKRRRV

[edit] Human Homologue Blast Result

subject ids% identity% positivesalignment length evalue
sp|P82912.2 44 61 109 3e-15
sp|P62263.3 34 58 117 2e-13
sp|Q9UH73.2 27 38 73 0.24
sp|Q12800.2 26 42 61 0.47
sp|Q8WW22.1 31 37 58 1.4

[edit] Alergen Protein

Link to Algpred
ALLERGEN (By IgE method) NON ALLERGEN

[edit] Bacterial Toxin Prediction

Link to btxpred
No Hit Fountd by btxpred server.

[edit] Subcellular Location

Link to TBpred
PROTEIN ATTACHED TO MEMBRANE BY LIPID ANCHOR

[edit] Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

[edit] B cell Epitopes

[edit] BCEpred Analysis

Link to Bcepred  
Result Predicited by [2]

[edit] ABCpred Analysis

Link to ABCpred
Result Predicited by[3]

[edit] IEDB Analysis

Link to IEDB
Result Predicited by [4]

[edit] MHC Class-I Binder

[edit] nHLAPred Analysis

Link to nHLApred
Result Predicited by [5]

[edit] IEDB Analysis

Link to IEDB
Result Predicted by [6]
Result Predicted by [7]


[edit] MHC Class-II Binder

[edit] Propred Analysis

Link to Propred
Result Predicted by[8]

[edit] NetMHC-II Analysis

Link to NetMHC-II
Result Predicted by [9]

[edit] External Links

  • Database of Mycobacterium tuberculosis genome sequences and related information.
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