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Immunotation of Rv3459c
Name
PROBABLE 30S RIBOSOMAL PROTEIN S11 RPSK
Identifiers
Swiss Prot	O06326
Genbank	[http://www.ncbi.nlm.nih.gov/nuccore/57116681?report=genbank&log$=seqview&from=3879273&to=3879692 NC_000962[1]]
PDB	2wdh
Chemical data
Formula	?
Mol. wt.	147848.8 Da
Pharmacokinetic data
Bioavailability	?
Solubility	?
Isoelectric-Point	12.22

1 General
- 1.1 Protein Sequence
2 Human Homologue Blast Result
3 Alergen Protein
4 Bacterial Toxin Prediction
5 Subcellular Location
6 Antigens
- 6.1 B cell Epitopes
7 MHC Class-I Binder
- 7.1 nHLAPred Analysis
- 7.2 IEDB Analysis
8 MHC Class-II Binder
- 8.1 Propred Analysis
- 8.2 NetMHC-II Analysis
9 External Links

[edit] General

S11 PLAYS AN ESSENTIAL ROLE FOR THE SELECTION OF THE CORRECT TRNA IN PROTEIN BIOSYNTHESIS. IT IS LOCATED ON THE LARGE LOBE OF THE SMALL SUBUNIT Rv3459c, (MTCY13E12.12c), len: 139 aa. Probable rpsK, 30S ribosomal protein S11, equivalent to Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S RIBOSOMAL PROTEIN S11 from Mycobacterium leprae (138 aa), FASTA scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa overlap); and P45812|RS11_MYCBO 30S RIBOSOMAL PROTEIN S11 from Mycobacterium bovis (139 aa), FASTA scores: opt: 867, E(): 8.4e-47, (94.25% identity in 139 aa overlap). Also highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 from Streptomyces coelicolor (134 aa), FASTA scores: opt: 729, E(): 2.6e-38, (79.85% identity in 139 aa overlap); O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 aa), FASTA scores: opt: 618, E(): 1.7e-31, (70.3% identity in 128 aa overlap); P04969|RS11_BACSU|RPSK from Bacillus subtilis (131 aa), FASTA scores: opt: 601, E(): 2e-30, (69.0% identity in 129 aa overlap); etc. Contains ribosomal protein S11 signature (PS00054). BELONGS TO THE S11P FAMILY OF RIBOSOMAL PROTEINS.

[edit] Protein Sequence

>Rv3459c, TB.seq 3879272:3879688 MW:14786

MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENA ARKAQDHGVRKVDVFVKGPGSGRETAIRSLQAAGLEVGAISDVTPQPHNGVRPPKRRRV

[edit] Human Homologue Blast Result

subject ids	% identity	% positives	alignment length	evalue
sp\|P82912.2	44	61	109	3e-15
sp\|P62263.3	34	58	117	2e-13
sp\|Q9UH73.2	27	38	73	0.24
sp\|Q12800.2	26	42	61	0.47
sp\|Q8WW22.1	31	37	58	1.4

[edit] Alergen Protein

Link to Algpred
ALLERGEN (By IgE method) NON ALLERGEN

[edit] Bacterial Toxin Prediction

Link to btxpred
No Hit Fountd by btxpred server.

[edit] Subcellular Location

Link to TBpred
PROTEIN ATTACHED TO MEMBRANE BY LIPID ANCHOR

[edit] Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

[edit] B cell Epitopes

[edit] BCEpred Analysis

Link to Bcepred
Result Predicited by [2]

[edit] ABCpred Analysis

Link to ABCpred
Result Predicited by[3]

[edit] IEDB Analysis

Link to IEDB
Result Predicited by [4]

[edit] MHC Class-I Binder

[edit] nHLAPred Analysis

Link to nHLApred
Result Predicited by [5]

[edit] IEDB Analysis

Link to IEDB
Result Predicted by [6]
Result Predicted by [7]

[edit] MHC Class-II Binder

[edit] Propred Analysis

Link to Propred
Result Predicted by[8]

[edit] NetMHC-II Analysis

Link to NetMHC-II
Result Predicted by [9]

[edit] External Links

Database of Mycobacterium tuberculosis genome sequences and related information.

@@ Line 5: / Line 5: @@
 |image2=
 |Swiss Prot =  O06326
-| Genbank          = 886959
+| Genbank          = NC_000962[http://www.ncbi.nlm.nih.gov/nuccore/57116681?report=genbank&log$=seqview&from=3879273&to=3879692]
 | PDB         = 	2wdh
 | DrugBank          =
-| chemical_formula  = [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=7711&loc=ec_rcs]
+| chemical_formula  =
-| molecular_weight  = 14786 Da
+| molecular_weight  = 147848.8 Da
 | solubility        =
-|Isoelectric-Point = 6.52
+|Isoelectric-Point = 12.22
 }}
 =General=
-S11 PLAYS AN ESSENTIAL ROLE FOR THE SELECTION OF THE CORRECT TRNA IN PROTEIN BIOSYNTHESIS.
+'''S11 PLAYS AN ESSENTIAL ROLE FOR THE SELECTION OF THE CORRECT TRNA IN PROTEIN BIOSYNTHESIS.
-IT IS LOCATED ON THE LARGE LOBE OF THE SMALL SUBUNIT
+IT IS LOCATED ON THE LARGE LOBE OF THE SMALL SUBUNIT'''
 Rv3459c, (MTCY13E12.12c), len: 139 aa. Probable rpsK, 30S ribosomal protein S11, equivalent to Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S RIBOSOMAL PROTEIN S11 from Mycobacterium leprae (138 aa), FASTA scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa overlap); and P45812|RS11_MYCBO 30S RIBOSOMAL PROTEIN S11 from Mycobacterium bovis (139 aa), FASTA scores: opt: 867, E(): 8.4e-47, (94.25% identity in 139 aa overlap). Also highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 from Streptomyces coelicolor (134 aa), FASTA scores: opt: 729, E(): 2.6e-38, (79.85% identity in 139 aa overlap); O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 aa), FASTA scores: opt: 618, E(): 1.7e-31, (70.3% identity in 128 aa overlap); P04969|RS11_BACSU|RPSK from Bacillus subtilis (131 aa), FASTA scores: opt: 601, E(): 2e-30, (69.0% identity in 129 aa overlap); etc. Contains ribosomal protein S11 signature (PS00054). BELONGS TO THE S11P FAMILY OF RIBOSOMAL PROTEINS.
@@ Line 21: / Line 21: @@
 >Rv3459c, TB.seq  3879272:3879688 MW:14786
-MPPAKKGPAT SARKGQKTRR REKKNVPHGA AHIKSTFNNT IVTITDPQGN VIAWASSGHV
+MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENA
+ARKAQDHGVRKVDVFVKGPGSGRETAIRSLQAAGLEVGAISDVTPQPHNGVRPPKRRRV
-         80         90        100        110        120
+=Human Homologue Blast Result=
-GFKGSRKSTP FAAQLAAENA ARKAQDHGVR KVDVFVKGPG SGRETAIRSL QAAGLEVGAI
+<table border='1'><tr>
-SDVTPQPHNG VRPPKRRRV
+<td>subject ids</td><td>% identity</td><td>% positives</td><td>alignment length</td><td> evalue</td></tr>
+<tr><td> sp|P82912.2</td><td>	44</td><td>	61</td><td>	109</td><td>	 3e-15 </td></tr>
+<tr><td> sp|P62263.3</td><td>	34</td><td>	58</td><td>	117</td><td>	2e-13</td></tr>
+<tr><td> sp|Q9UH73.2</td><td>	27</td><td>	38</td><td>	73</td><td>	0.24</td></tr>
+<tr><td> sp|Q12800.2</td><td>	26</td><td>	42</td><td>	61</td><td>	0.47</td></tr>
+<tr><td> sp|Q8WW22.1</td><td>	31</td><td>	37</td><td>	58</td><td>	1.4</td></tr></table>
+=Alergen Protein=
+Link to [http://www.imtech.res.in/raghava/algpred/ Algpred]<br>
+ALLERGEN (By IgE method)
+NON ALLERGEN
+=Bacterial Toxin Prediction=
+Link to [http://www.imtech.res.in/raghava/btxpred/submission.html btxpred]<br>
+No Hit Fountd by btxpred server.
+=Subcellular Location=
+Link to [http://www.imtech.res.in/raghava/tbpred/ TBpred]<br>
+PROTEIN ATTACHED TO MEMBRANE BY LIPID ANCHOR
+=Antigens=
+No Hit Found in [http://www.imtech.res.in/raghava/antigendb/keyquery.html AntigenDB]<br>
+No. Hit Found in [http://www.iedb.org/ IEDB]
+==B cell Epitopes==
+====BCEpred Analysis====
+Link to [http://www.imtech.res.in/raghava/bcepred/bcepred_submission.html Bcepred]
+<br>
+Result Predicited by [http://crdd.osdd.net/drugpedia/index.php/Image:ABCpred_Prediction_Server3459c.doc]<br>
+====ABCpred Analysis====
+Link to [http://www.imtech.res.in/raghava/abcpred/ABC_submission.html ABCpred]<br>
+Result Predicited by[http://crdd.osdd.net/drugpedia/index.php/Image:BcePred_Prediction_Serverresult_3459c.doc]<br>
+====IEDB Analysis====
+Link to [http://tools.immuneepitope.org/tools/bcell/iedb_input IEDB]<br>
+Result Predicited by [http://crdd.osdd.net/drugpedia/index.php/Image:IEDB_Analysis_Resource3459c.doc]<br>
+=MHC Class-I Binder=
+==nHLAPred Analysis==
+Link to [http://www.imtech.res.in/raghava/nhlapred/comp.html nHLApred]
+<br>
+Result Predicited by [http://crdd.osdd.net/drugpedia/index.php/Image:NHLAPred3459c.doc]<br>
+==IEDB Analysis==
+Link to [http://tools.immuneepitope.org/analyze/html/mhc_processing.html IEDB] <br>
+Result Predicted by [http://crdd.osdd.net/drugpedia/index.php/Image:IEDB_Analysis_Resource3459c_MHC1-1.doc]<br>
+Result Predicted by [http://crdd.osdd.net/drugpedia/index.php/Image:MHC-1-2.doc]<br>
+=MHC Class-II Binder=
+==Propred Analysis==
+Link to [http://www.imtech.res.in/raghava/propred/ Propred]<br>
+Result Predicted by[http://crdd.osdd.net/drugpedia/index.php/Image:MHC_Class-II_prophed3459c.doc]<br>
+==NetMHC-II Analysis==
+Link to [http://www.cbs.dtu.dk/services/NetMHCII/ NetMHC-II]<br>
+Result Predicted by [http://crdd.osdd.net/drugpedia/index.php/Image:NetMHCII3459c.doc]
+=External Links=
+* [http://www.biohealthbase.org/mycobacterium Database] of ''Mycobacterium tuberculosis'' genome sequences and related information.
+[[Category:C2D]]
+[[Category:Mtb Immunotation]]

Immunotation of Rv3459c

From DrugPedia: A Wikipedia for Drug discovery

Current revision

Contents

[edit] General

[edit] Protein Sequence

[edit] Human Homologue Blast Result

[edit] Alergen Protein

[edit] Bacterial Toxin Prediction

[edit] Subcellular Location

[edit] Antigens

[edit] B cell Epitopes

[edit] BCEpred Analysis

[edit] ABCpred Analysis

[edit] IEDB Analysis

[edit] MHC Class-I Binder

[edit] nHLAPred Analysis

[edit] IEDB Analysis

[edit] MHC Class-II Binder

[edit] Propred Analysis

[edit] NetMHC-II Analysis

[edit] External Links

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