Rv2747
From DrugPedia: A Wikipedia for Drug discovery
(New page: {{immunebox | Name =<b> N-acetylglutamate synthase </b> |image= | width=250 |image2= |Swiss Prot = O33289 | Genbank = 888407 | PDB = 3FIG, 1SR9 | DrugBank ...) |
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|Swiss Prot = O33289 | |Swiss Prot = O33289 | ||
| Genbank = 888407 | | Genbank = 888407 | ||
| - | | PDB = | + | | PDB = |
| DrugBank = | | DrugBank = | ||
| chemical_formula = C18H20ClNO3 [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pccompound&term=888407] | | chemical_formula = C18H20ClNO3 [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pccompound&term=888407] | ||
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<td>subject ids</td><td>% identity</td><td>% positives</td><td>alignment length</td><td> evalue</td></tr> | <td>subject ids</td><td>% identity</td><td>% positives</td><td>alignment length</td><td> evalue</td></tr> | ||
| - | <tr><td>sp|Q9UHF3.1</td><td> 31</td><td> 40</td><td> 118</td><td> 0. | + | <tr><td>sp|Q9UHF3.1</td><td> 31</td><td> 40</td><td> 118</td><td> 0.029 </td></tr> |
<tr><td>sp|Q9H967.1</td><td> 29</td><td> 42</td><td> 87</td><td> 0.73 </td></tr> | <tr><td>sp|Q9H967.1</td><td> 29</td><td> 42</td><td> 87</td><td> 0.73 </td></tr> | ||
| Line 45: | Line 45: | ||
<tr><td>sp|Q8IY67.1</td><td> 27</td><td> 40</td><td> 93</td><td> 2.5 </td></tr> | <tr><td>sp|Q8IY67.1</td><td> 27</td><td> 40</td><td> 93</td><td> 2.5 </td></tr> | ||
| - | <tr><td>sp|Q9Y2K9.2</td><td> 27</td><td> 47</td><td> 61</td><td> | + | <tr><td>sp|Q9Y2K9.2</td><td> 27</td><td> 47</td><td> 61</td><td> 4.3 </td></tr> |
<tr><td>sp|Q92621.2</td><td> 31</td><td> 45</td><td> 72</td><td> 7.5 </td></tr></table> | <tr><td>sp|Q92621.2</td><td> 31</td><td> 45</td><td> 72</td><td> 7.5 </td></tr></table> | ||
Current revision
| Rv2747
| |
| Name | |
| N-acetylglutamate synthase | |
| Identifiers | |
| Swiss Prot | |
| Genbank | |
| PDB | ? |
| Chemical data | |
| Formula | C18H20ClNO3 [1] |
| Mol. wt. | 19557 Da |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Solubility | ? |
| Isoelectric-Point | 5.27 |
Contents |
[edit] General
INVOLVED IN ARGININE BIOSYNTHESIS [CATALYTIC ACTIVITY: L-GLUTAMATE + ACETYL-COA <=> N-ACETYL-L-GLUTAMATE + COENZYME A]
Essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003) mutants available at TARGET website
[edit] Protein Sequence
>Rv2747, TB.seq 3059259:3059780 MW:19557 VTERPRDCRPVVRRARTSDVPAIKQLVDTYAGKILLEKNLVTLYEAVQEFWVAEHPDLYGKVVGCGALHVLWSDLGEIRT VAVDPAMTGHGIGHAIVDRLLQVARDLQLQRVFVLTFETEFFARHGFTEIEGTPVTAEVFDEMCRSYDIGVAEFLDLSYV KPNILGNSRMLLVL
[edit] Human Homologue Blast Result
| subject ids | % identity | % positives | alignment length | evalue |
| sp|Q9UHF3.1 | 31 | 40 | 118 | 0.029 |
| sp|Q9H967.1 | 29 | 42 | 87 | 0.73 |
| sp|Q8IY67.1 | 27 | 40 | 93 | 2.5 |
| sp|Q9Y2K9.2 | 27 | 47 | 61 | 4.3 |
| sp|Q92621.2 | 31 | 45 | 72 | 7.5 |
[edit] Alergen Protein
Link to Algpred
Non Allergen Predicted by AlgPred Server
[edit] Bacterial Toxin Prediction
Link to btxpred
No Hit Fountd by btxpred server.
[edit] Subcellular Location
Link to TBpred
Cytoplasmic
[edit] Antigens
No Hit Found in AntigenDB
No. Hit Found in IEDB
[edit] B cell Epitopes
[edit] BCEpred Analysis
Link to Bcepred
Result Predicited by [2]
[edit] ABCpred Analysis
Link to ABCpred
Result Predicited by [3]
[edit] IEDB Analysis
Link to IEDB
Result Predicited by [4]
[edit] MHC Class-I Binder
[edit] nHLAPred Analysis
Link to nHLApred
Result Predicited by [5]
[edit] IEDB Analysis
Link to IEDB
Result Predicted by [6]
[edit] MHC Class-II Binder
[edit] Propred Analysis
Link to Propred
Result Predicted by [7]
[edit] NetMHC-II Analysis
Link to NetMHC-II
Result Predicted by [8]
[edit] External Links
- Database of Mycobacterium tuberculosis genome sequences and related information.
