ADMET
From DrugPedia: A Wikipedia for Drug discovery
(New page: '''ADME''' absorption, distribution, metabolism, and excretion, describes the disposition of a pharmaceutical compound within an organism. These four criterias influence the drug level an...) |
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'''ADME''' absorption, distribution, metabolism, and excretion, describes the disposition of a pharmaceutical compound within an organism. These four criterias influence the drug level and kinetics of drug exposure to the tissues and hence influence the performance and pharmacological activity of the compound as a drug. | '''ADME''' absorption, distribution, metabolism, and excretion, describes the disposition of a pharmaceutical compound within an organism. These four criterias influence the drug level and kinetics of drug exposure to the tissues and hence influence the performance and pharmacological activity of the compound as a drug. | ||
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| + | All xenobiotics (molecules that are alien to your body) are affected by these natural processes in the human body. Absorption determines if the drug gets into the body (passing of the gastro-intestinal tract), distribution determines if the drug can arrive at the place of action, metabolism determines whether the drug is broken down before it can arrive at place of action and excretion determines whether the drug is gone before / too soon after it can become active. ADME plays an ever increasingly important role in the drug design process. | ||
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| + | ==Absorption== | ||
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| + | ==Distribution== | ||
| + | ==Metabolism== | ||
| + | ==Excretion== | ||
| + | ==Toxicology== | ||
Revision as of 17:40, 5 August 2008
ADME absorption, distribution, metabolism, and excretion, describes the disposition of a pharmaceutical compound within an organism. These four criterias influence the drug level and kinetics of drug exposure to the tissues and hence influence the performance and pharmacological activity of the compound as a drug.
All xenobiotics (molecules that are alien to your body) are affected by these natural processes in the human body. Absorption determines if the drug gets into the body (passing of the gastro-intestinal tract), distribution determines if the drug can arrive at the place of action, metabolism determines whether the drug is broken down before it can arrive at place of action and excretion determines whether the drug is gone before / too soon after it can become active. ADME plays an ever increasingly important role in the drug design process.
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