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==Establishing protein-protein interactions==

Most proteins function in collaboration with other proteins, and one goal of proteomics is to identify which proteins interact.  This is especially useful in determing potential partners in [[cell signalling]] cascades.

Several methods are available to probe protein-protein interactions.  The traditional method is yeast [[Two-hybrid screening|two-hybrid analysis]].  New methods include [[protein microarray]]s, [[immunoaffinity chromatography]] followed by [[mass spectrometry]], and combinations of experimental methods such as phage display and computational methods.